Toxicity Mechanism That Causes Parkinson’s Disease Identified
Written by WTJ on January 2, 2009 – 10:41 am -Researchers at Emory University School of Medicine have identified a possible toxicity mechanism that causes Parkinson’s disease.
Lewy body is abnormal aggregated proteins inside cells. Neurologists have observed in the damaged parts of brains in the patients with neurodegenerative diseases such as Parkinson’s disease for decades. The appearance of Lewy body shows that protein recycling and waste disposal could be the reason that leads to Parkinson’s disease.
A study that is going to be published in Jan 2, 2009 issue of Science shows a possible toxicity pathway that kill the brain cells and cause Parkinson’s disease. A protein component of Lewy body, alpha-synuclein, is interfering with the recycling of MEF2D. This explains why MEF2D is abundant in patients with Parkinson’s disease. MEF2D is a transcription factor that regulates the activity of the gene. It binds to DNA to control the gene, hence controlling development and survival of brain cells, as shown in many studies.
This finding helps researcher understand the pathway for controlling cell loss and survival in Parkinson’s disease, hence develop drugs which help MEF2D to be more toxic resistance.
(news)
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Tags: alpha-synuclein, Emanuela Colla, Emory University, Emory University School of Medicine, Hua She, John J. Shacka, lewy body, Marla Gearing, MEF2D, Michael Lee, neurodegenerative disease, neurology, Parkinson's disease, Qian Yang, science, transcription factor, Zixu Mao | 1 Comment »
January 13th, 2009 at 11:34 pm
[...] Nanotechnology, Neuroscience and Research. One of the recent posts on the blog focuses on the causes of Parkinson’s disease. A study done by Emory University School of Medicine found toxicity mechanisms that cause [...]