Nerdy Science Blog

Paul Bryce from Feingberg School of Medicine of Northwestern University had successfully developed the world first peanut allergy mouse.  Peanut allergy is a common food allergy.  Peanut allergy is an anaphylactic reaction, an acute systemic and severe type I hypersensitivity allergic reaction.  Paul Bryce and colleagues induced anaphylaxis in rodent by feeding it with whole peanut extract and toxin from bacteria Staphylococcus aureus, staphylococca enterotoxin B.  They successfully triggered human anaphylactic reaction to peanuts in mice.  This development of new model of food allergy could bring the research in food allergy a step forward by understanding the unknown pathogenesis and mechanisms of food allergic response.  No more peanut butter for mice!

The study is published in January’s issue of The Journal of Allergy and Clinical Immunology.  Other authors are Kirthana Ganeshan, Colleen V. Neilsen, April Hadsaitong, Robert P. Schleimer, and Xunrong Luo.

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